IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Roghani M., Segovia B., Whitechurch O., Binoux M.Growth Regul. 1:125-130(1991) Ikonen M., Liu B., Hashimoto Y., Ma L. Cohen P.Proc. Natl. Acad. Sci. U.S.A. 100:13042-13047(2003)Zhou W., Ross M.M., Tessitore A. J. Proteome Res. 8:5523-5531(2009)
Host
Rabbit
Immunogen
Peptide sequence around aa.185~189(R-Y-K-V-D) derived from Human IGFBP-3.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Roghani M., Segovia B., Whitechurch O., Binoux M.Growth Regul. 1:125-130(1991) Ikonen M., Liu B., Hashimoto Y., Ma L. Cohen P.Proc. Natl. Acad. Sci. U.S.A. 100:13042-13047(2003) Zhou W., Ross M.M., Tessitore A. J. Proteome Res. 8:5523-5531(2009)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total IGFBP-3 protein.
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Pathway
p53 signaling pathway Cellular senescence
Tissue Specificity
Expressed by most tissues. Present in plasma.
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.