This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.Kohen R., J. Neurochem. 66:47-56(1996).Kopatz S.A., Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.Gregory S.G., Nature 441:315-321(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human 5-HT-6.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.
Kohen R., J. Neurochem. 66:47-56(1996). Kopatz S.A., Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. Gregory S.G., Nature 441:315-321(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total 5-HT-6 protein.
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling
Pathway
Calcium signaling pathway cAMP signaling pathway
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Expressed in several human brain regions, most prominently in the caudate nucleus.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.