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Home / Primary Antibodies

HSPA8 Antibody

SKU : BHA10558821

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA162061
Alternative Names	BRODL; bromodomain and WD repeat domain containing 3; FLJ38568;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.Muraki T., Mol. Pharmacol. 58:1257-1263(2000).Quadroni M., Submitted (MAR-2009).Keith W.N., Submitted (JAN-2010).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human HSPA8.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Muraki T., Mol. Pharmacol. 58:1257-1263(2000). Quadroni M., Submitted (MAR-2009). Keith W.N., Submitted (JAN-2010).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total HSPA8 protein.
Subcellular Location	Cytoplasm, Melanosome, Nucleus, nucleolus, Cell membrane

Uniprot	P11142
Database Links	HGNC:5241 OMIM:600816 KEGG:hsa:3312 STRING:9606.ENSP00000227378 UniGene:Hs.180414
Function	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation
Pathway	Estrogen signaling pathway MAPK signaling pathway Protein processing in endoplasmic reticulum Antigen processing and presentation Endocytosis
Protein Families	Heat shock protein 70 family
Tissue Specificity	Ubiquitous.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558821	CSB-PA162061	100ul	$297		Add to Cart

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