Forkhead box protein E1; Thyroid transcription factor 2; TTF-2; Forkhead-related protein FKHL15; FKHL15
Antigen
FoxE1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Probable transcription factor. Could be involved in thyroid gland organogenesis.Chadwick B.P., Genomics 41:390-396(1997).Macchia P.E., Biochimie 81:433-440(1999).Baris I., J. Clin. Endocrinol. Metab. 91:4183-4187(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human TTF2.
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
Tissue Specificity
Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.