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Home / Primary Antibodies / Polyclonal Antibodies

FKBP1A antibody

SKU : BHA10803130

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Mfr.No.	FNab03136
Alternative Names	FKBP1 ; FKBP12
Background	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Host	Rabbit
Immunogen	FK506 binding protein 1A, 12kDa
Isotype	IgG
Molecular Weight	12 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	FKBP1, FKBP12

Uniprot	P62942
Gene Id	2280
Research Area	Immunology, Signal Transduction, Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB
Description	ELISA ; IHC ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab03136.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10803130	FNab03136	100ug	$280		Add to Cart

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