Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling.Smallwood P.M., Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).Gecz J., Hum. Genet. 104:56-63(1999).Ross M.T., Nature 434:325-337(2005).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human FGF13.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling.
Smallwood P.M., Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996). Gecz J., Hum. Genet. 104:56-63(1999). Ross M.T., Nature 434:325-337(2005).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total FGF13 protein.
Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.
Protein Families
Heparin-binding growth factors family
Tissue Specificity
Ubiquitously expressed. Predominantly expressed in the nervous system.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.