a maternal imprinting gene. May possess growth suppressor activity. Two major alternatively spliced isoforms have been described. forms. One form, Meg3-proximal (Meg3p), contains exons 1-3. The second form, Meg3-distal (Meg3d) did not contain exons 1-3 and was present in oocytes and in 1- and 2-cell embryos Adachi H, Majima S, et al. Oncogene. 2004 Apr 22;23(19):3495-500 Matsumoto F, Fujii H, et al. Hum Pathol. 2006 Dec; 37(12):1592-600.
Host
Rabbit
Immunogen
Peptide sequence around aa.710~714 (Q-V-S-S-P) derived from Human Niban-like protein.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
a maternal imprinting gene. May possess growth suppressor activity. Two major alternatively spliced isoforms have been described. forms. One form, Meg3-proximal (Meg3p), contains exons 1-3. The second form, Meg3-distal (Meg3d) did not contain exons 1-3 and was present in oocytes and in 1- and 2-cell embryos
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
Protein Families
Niban family
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.