DNA repair endonuclease XPF; EC 3.1.-.-; DNA excision repair protein ERCC-4; DNA-repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein, DNA repair endonuclease XPF; EC 3.1.-.-; DNA excision repair protein ERCC-4; DNA-repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein
Antigen
ERCC4
Categories
Primary Antibodies, Primary Antibodies
Clonality
polyclonal
Description
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.Brookman K.W., Mol. Cell. Biol. 16:6553-6562(1996).Sijbers A.M., Cell 86:811-822(1996).Cleaver J.E., Hum. Mutat. 14:9-22(1999)., Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.Brookman K.W., Mol. Cell. Biol. 16:6553-6562(1996).Sijbers A.M., Cell 86:811-822(1996).Cleaver J.E., Hum. Mutat. 14:9-22(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human XPF., Synthesized peptide derived from internal of Human XPF.
Involvement In Disease
Xeroderma pigmentosum complementation group F (XP-F); XFE progeroid syndrome (XFEPS); Xeroderma pigmentosum type F/Cockayne syndrome (XPF/CS); Fanconi anemia complementation group Q (FANCQ)
Raised In
Rabbit
Reactivity
Human, Mouse, Mouse
Regulatory
RUO
Relevance
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
Pathway
DNA repair pathway, DNA repair pathway
Protein Families
XPF family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol., Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.