Epidermal growth factor receptor kinase substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-like protein 2; EPS8L2; EPS8R2
Antigen
Eps8L2
Categories
Primary Antibodies
Clonality
polyclonal
Description
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.Tocchetti A., Genomics 81:234-244(2003).Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).Offenhaeuser N., Mol. Biol. Cell 15:91-98(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ES8L2.
Involvement In Disease
Deafness, autosomal recessive, 106 (DFNB106)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
Tocchetti A., Genomics 81:234-244(2003). Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004). Offenhaeuser N., Mol. Biol. Cell 15:91-98(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ES8L2 protein.
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
Protein Families
EPS8 family
Tissue Specificity
Detected in fibroblasts and placenta.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.