Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. soform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.Taylor T.D., Nature 440:497-500(2006).Ota T., Nat. Genet. 36:40-45(2004).Oettgen P., J. Biol. Chem. 274:29439-29452(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ELF5.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. soform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
Taylor T.D., Nature 440:497-500(2006). Ota T., Nat. Genet. 36:40-45(2004). Oettgen P., J. Biol. Chem. 274:29439-29452(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ELF5 protein.
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.
Protein Families
ETS family
Tissue Specificity
Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tiss
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.