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Home / Primary Antibodies

EFNB2 (Ab-330) Antibody

SKU : BHA10559018

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA077593
Alternative Names	EFNB2; HTKL; LERK5
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. Chrencik JE,et al.( 2006) J Biol Chem;281(38):28185-28192. Kertesz N, et al. (2006) Blood; 107(6):2330-2338. Noren NK, et al. (2004) Proc Natl Acad Sci USA; 101(15):5583-5588.
Host	Rabbit
Immunogen	Peptide sequence around aa.328~332 (N-I-Y-Y-K) derived from Human Ephrin B (ephrin-B2).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. Chrencik JE,et al.( 2006) J Biol Chem;281(38):28185-28192. Kertesz N, et al. (2006) Blood; 107(6):2330-2338. Noren NK, et al. (2004) Proc Natl Acad Sci USA; 101(15):5583-5588.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total Ephrin-B2 protein.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	P52799
Database Links	HGNC:3227 OMIM:600527 KEGG:hsa:1948 STRING:9606.ENSP00000245323 UniGene:Hs.149239
Function	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Families	Ephrin family
Tissue Specificity	Lung and kidney.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:1000
IF	1:100-1:200

Tested Application

ELISA,WB,IF;WB:1:500-1:1000,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559018	CSB-PA077593	100ul	$297		Add to Cart

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