Docking protein 4; Downstream of tyrosine kinase 4; DOK4;
Antigen
DOK4
Categories
Primary Antibodies
Clonality
polyclonal
Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway By similarity. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.Favre C., Genes Immun. 4:40-45(2003).Cai D., J. Biol. Chem. 278:25323-25330(2003).Loftus B.J., Genomics 60:295-308(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human DOK4.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway By similarity. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
Favre C., Genes Immun. 4:40-45(2003). Cai D., J. Biol. Chem. 278:25323-25330(2003). Loftus B.J., Genomics 60:295-308(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total DOK4 protein.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
Protein Families
DOK family, Type B subfamily
Tissue Specificity
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.