180 kDa protein downstream of CRK; dedicator of cytokinesis protein 1; DOC1; DOCK180;
Antigen
DOCK1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996).Deloukas P., Nature 429:375-381(2004).Matsuda M., J. Biol. Chem. 271:14468-14472(1996).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human DOCK1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996). Deloukas P., Nature 429:375-381(2004). Matsuda M., J. Biol. Chem. 271:14468-14472(1996).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total DOCK1 protein.
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen
Pathway
Focal adhesion Regulation of actin cytoskeleton
Protein Families
DOCK family
Tissue Specificity
Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.