2; 4-dienoyl CoA reductase 2; peroxisomal; EC 1.3.1.34;
Antigen
DECR2
Categories
Primary Antibodies
Clonality
polyclonal
Description
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.De Nys K., Biochim. Biophys. Acta 1533:66-72(2001).Daniels R.J., Hum. Mol. Genet. 10:339-352(2001).Ota T., Nat. Genet. 36:40-45(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human DECR2.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
De Nys K., Biochim. Biophys. Acta 1533:66-72(2001). Daniels R.J., Hum. Mol. Genet. 10:339-352(2001). Ota T., Nat. Genet. 36:40-45(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total DECR2 protein.
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.