Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.Higashi Y., Proc. Natl. Acad. Sci. U.S.A. 83:2841-2845(1986).White P.C., Proc. Natl. Acad. Sci. U.S.A. 83:5111-5115(1986).Rodrigues N.R., EMBO J. 6:1653-1661(1987).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human CYP21A2.
Involvement In Disease
Adrenal hyperplasia 3 (AH3)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
Higashi Y., Proc. Natl. Acad. Sci. U.S.A. 83:2841-2845(1986). White P.C., Proc. Natl. Acad. Sci. U.S.A. 83:5111-5115(1986). Rodrigues N.R., EMBO J. 6:1653-1661(1987).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CYP21A2 protein.