CREM-alpha; cAMP-responsive element modulator; cAMP-responsive element modulator; alpha isoform CREM; CREM-beta
Antigen
CREM
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation By similarity.Masquilier D., Cell Growth Differ. 4:931-937(1993).Meyer T.E., Nucleic Acids Res. 20:6106-6106(1992).Fujimoto T., J. Biochem. 115:298-303(1994).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CREM.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation By similarity.
Masquilier D., Cell Growth Differ. 4:931-937(1993). Meyer T.E., Nucleic Acids Res. 20:6106-6106(1992). Fujimoto T., J. Biochem. 115:298-303(1994).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CREM protein.
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation
Protein Families
BZIP family
Tissue Specificity
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.