Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.Tanihara H., Cell Adhes. Commun. 2:15-26(1994).Okazaki M., J. Biol. Chem. 269:12092-12098(1994).Suzuki S., Cell Regul. 2:261-270(1991).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CDH11.
Involvement In Disease
A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Tanihara H., Cell Adhes. Commun. 2:15-26(1994). Okazaki M., J. Biol. Chem. 269:12092-12098(1994). Suzuki S., Cell Regul. 2:261-270(1991).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CDH11 protein.
Subcellular Location
Cell membrane, Single-pass type I membrane protein
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Tissue Specificity
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.