Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 3; Carma 1; CARD11; CARMA1
Antigen
CARD11
Categories
Primary Antibodies
Clonality
polyclonal
Description
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.Bertin J., J. Biol. Chem. 276:11877-11882(2001).Gaide O., FEBS Lett. 496:121-127(2001).Hillier L.W., Nature 424:157-164(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CARD11.
Involvement In Disease
B-cell expansion with NFKB and T-cell anergy (BENTA); Immunodeficiency 11 A (IMD11A); Immunodeficiency 11B with atopic dermatitis (IMD11B)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Bertin J., J. Biol. Chem. 276:11877-11882(2001). Gaide O., FEBS Lett. 496:121-127(2001). Hillier L.W., Nature 424:157-164(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CARD11 protein.
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.
Pathway
NF-kappa B signaling pathway B cell receptor signaling pathway T cell receptor signaling pathway
Tissue Specificity
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in H
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.