GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.Sattler M, et al. Mol Cell Biol. 1999 Nov; 19(11): 7473-7480.Li S et al. EMBO J. 2001 Dec 3; 20(23): 6793-6804.Million RP, et,al. Mol Cell Biol. 2004 Jun; 24(11): 4685-4695.Malcolm A. Meyn, et al. . Biol. Chem., Oct 2006; 281: 30907
Host
Rabbit
Immunogen
Peptide sequence around aa. 175~179 (P-F-Y-V-N) derived from Human Bcr.
Involvement In Disease
Leukemia, chronic myeloid (CML)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
Sattler M, et al. Mol Cell Biol. 1999 Nov; 19(11): 7473-7480. Li S et al. EMBO J. 2001 Dec 3; 20(23): 6793-6804. Million RP, et,al. Mol Cell Biol. 2004 Jun; 24(11): 4685-4695. Malcolm A. Meyn, et al. . Biol. Chem., Oct 2006; 281: 30907
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total Bcr protein.
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.