Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.Zheng H., DNA Seq. 15:303-305(2004).Hampe J., Nat. Genet. 39:207-211(2007).Clark H.F., Genome Res. 13:2265-2270(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from Internal of Human ATG16L1.
Involvement In Disease
Inflammatory bowel disease 10 (IBD10)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
Zheng H., DNA Seq. 15:303-305(2004). Hampe J., Nat. Genet. 39:207-211(2007). Clark H.F., Genome Res. 13:2265-2270(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ATG16L1 protein.
Subcellular Location
Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein