Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.White J.H., Proc. Natl. Acad. Sci. U.S.A. 97:13967-13972(2000).Yamada S., Oncogene 23:5901-5911(2004).Liu W., Biochem. Biophys. Res. Commun. 321:954-960(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ATF5.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.
White J.H., Proc. Natl. Acad. Sci. U.S.A. 97:13967-13972(2000). Yamada S., Oncogene 23:5901-5911(2004). Liu W., Biochem. Biophys. Res. Commun. 321:954-960(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ATF5 protein.
Subcellular Location
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus
Protein Families
BZIP family
Tissue Specificity
Widely expressed with higher expression levels in liver.
Weight
30,674 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.