This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Chen B.P.C., J. Biol. Chem. 269:15819-15826(1994).Hai T., Genes Dev. 3:2083-2090(1989).Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ATF3.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Chen B.P.C., J. Biol. Chem. 269:15819-15826(1994). Hai T., Genes Dev. 3:2083-2090(1989). Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ATF3 protein.