Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.Zannis V.I., J. Biol. Chem. 259:5495-5499(1984).McLean J.W., J. Biol. Chem. 259:6498-6504(1984).Paik Y.-K., Proc. Natl. Acad. Sci. U.S.A. 82:3445-3449(1985).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human APOE.
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Zannis V.I., J. Biol. Chem. 259:5495-5499(1984). McLean J.W., J. Biol. Chem. 259:6498-6504(1984). Paik Y.-K., Proc. Natl. Acad. Sci. U.S.A. 82:3445-3449(1985).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total APOE protein.
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Pathway
Cholesterol metabolism
Protein Families
Apolipoprotein A1/A4/E family
Tissue Specificity
Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, a
Weight
36
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.