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Home / Primary Antibodies / IHC Antibodies

Anti-PRKN Antibody BHA11300448

SKU : BHA11300448

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Mfr.No.	BS1284
Alternative Names	E3 ubiquitin-protein ligase parkin ; Parkinson juvenile disease protein 2 ; Parkinson disease protein 2 ; PARK2 ; PRKN
Antigen	PRKN
Categories	Primary Antibodies
Chromosome Location	6q26
Clonality	polyclonal
Description	Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2- 27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms ranging from 50-58 kDa. Mutations in the Parkin gene are responsible for utosomal recessive juvenile Parkinson’s disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 1-50 of Human PARK2.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O60260
Uniprot	O60260
Weight	52 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: Parkin (G12) polyclonal antibody detects endogenous levels of Parkin protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC, IF

Description

IHC ; IF

Dilution

IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300448	BS1284	50µl	$190.44		Add to Cart
BHA11300448	BS1284	100µl	$294.44		Add to Cart

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