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Home / Primary Antibodies / Recombinant Antibodies

Anti-PHC3 Antibody BHA11308149

SKU : BHA11308149

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Mfr.No.	BS8250
Alternative Names	Polyhomeotic-like protein 3 ; Early development regulatory protein 3 ; Homolog of polyhomeotic 3 ; hPH3 ; PHC3 ; EDR3 ; PH3
Antigen	PHC3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Loss of heterozygosity of the PHC3 gene was observed in human osteosarcoma tumors, suggesting that loss of PHC3 protein may contribute to tumorigenesis. There are six isoforms of PHC3 that are expressed as a result of alternative splicing events.
Host	Rabbit
Immunogen	Recombinant full length Human PHC3.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO

Swissprot	Q8NDX5
Uniprot	Q8NDX5
Weight	106 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: PHC3 polyclonal antibody detects endogenous levels of PHC3 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:2000
IF	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308149	BS8250	50µl	$234.89		Add to Cart
BHA11308149	BS8250	100µl	$368.22		Add to Cart

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