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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Histone deacetylase 8 HDAC8 Antibody Picoband®

SKU : BHA21006910

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Mfr.No.	PA1591, PA1591-10ug, PA1591-Biotin, PA1591-Cy3, PA1591-Dylight488, PA1591-Dylight550, PA1591-Dylight594, PA1591-FITC, PA1591-HRP, PA1591-APC, PA1591-PE, PA1591-iFluor647, PA1591-carrier-free
Alternative Names	Histone deacetylase 8
Background	HDAC8, Histone deacetylase 8, is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Sequence analysis predicted that the 377-amino acid HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function. HDAC8 shares 54% sequence similarity with HDAC1 and HDAC2 and 39% similarity with HDAC3, making it a class I HDAC. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Histone deacetylase 8 HDAC8 Antibody catalog # PA1591. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progr
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human HDAC8, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	42 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Histone deacetylase 8;HD8;3.5.1.98;HDAC8;HDACL1;CDA07;
Tissue Specificity	Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9BY41
Gene Name	HDAC8
Subcellular Location	Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Buggy, J. J., Sideris, M. L., Mak, P., Lorimer, D. D., McIntosh, B., Clark, J. M.Cloning and characterization of a novel human histone deacetylase, HDAC8.Biochem. J. 350: 199-205, 2000.<br /><br />2. Hu, E., Chen, Z., Fredrickson, T., Zhu, Y., Kirkpatrick, R., Zhang, G.-F., Johanson, K., Sung, C.-M., Liu, R., Winkler, J.Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor.J. Biol. Chem. 275: 15254-15264, 2000.<br /><br />3. Vannini, A., Volpari, C., Filocamo, G., Casavola, E. C., Brunetti, M., Renzoni, D., Chakravarty, P., Paolini, C., De Francesco, R., Gallinari, P., Steinkuhler, C., Di Marco, S.Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.Proc. Nat. Acad. Sci. 101: 15064-15069, 2004.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006910-1	PA1591	-	100 ug	$370		Add to Cart
BHA21006910-2	PA1591-10ug	Sample	10 ug	$99		Add to Cart
BHA21006910-3	PA1591-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006910-4	PA1591-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006910-5	PA1591-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006910-6	PA1591-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006910-7	PA1591-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006910-8	PA1591-FITC	FITC	100 ug	$570		Add to Cart
BHA21006910-9	PA1591-HRP	HRP	100 ug	$570		Add to Cart
BHA21006910-10	PA1591-APC	APC	100 ug	$670		Add to Cart
BHA21006910-11	PA1591-PE	PE	100 ug	$670		Add to Cart
BHA21006910-12	PA1591-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006910-13	PA1591-carrier-free	carrier-free	100 ug	$370		Add to Cart

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