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Home / Primary Antibodies / IHC Antibodies

Anti-HDAC4 Antibody BHA11300564

SKU : BHA11300564

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Mfr.No.	BS1403
Alternative Names	Histone deacetylase 4 ; HD4 ; HDAC4 ; KIAA0288
Categories	Primary Antibodies
Chromosome Location	2q37.3
Clonality	polyclonal
Description	In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, p300/CBP, PCAF (p300/CBPassociated factor), HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 600-650 of Human HDAC4.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P56524
Uniprot	P56524
Weight	119 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: HDAC4 (P626) polyclonal antibody detects endogenous levels of HDAC4 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300564	BS1403	50µl	$190.44		Add to Cart
BHA11300564	BS1403	100µl	$294.44		Add to Cart

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