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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FLI1 Antibody Picoband®

SKU : BHA21007375

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Mfr.No.	PA2179, PA2179-10ug, PA2179-Biotin, PA2179-Cy3, PA2179-Dylight488, PA2179-Dylight550, PA2179-Dylight594, PA2179-FITC, PA2179-HRP, PA2179-APC, PA2179-PE, PA2179-iFluor647, PA2179-carrier-free
Alternative Names	Friend leukemia integration 1 transcription factor
Background	Friend leukemia integration 1 transcription factor, also known as Transcription factor ERGB or Proto-oncogene Fli-1 is a protein that in humans is encoded by the human FLI1 gene. The fli1 protooncogene encodes a member of the ETS family of winged helix-tu-helix transcription factors. This gene is mapped to 11q24.3. Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias. The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event (s) associated with terminal differentiation to proliferation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-FLI1 Antibody catalog # PA2179. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C(CA)GGAAGT-3'.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human FLI1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	53 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Friend leukemia integration 1 transcription factor;Proto-oncogene Fli-1;Transcription factor ERGB;FLI1;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q01543
Gene Name	FLI1
Sequence	Belongs to the ETS family.
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Donaldson, I. J., Chapman, M., Kinston, S., Landry, J. R., Knezevic, K., Piltz, S., Buckley, N., Green, A. R., Gottgens, B. Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development. Hum. Molec. Genet. 14: 595-601, 2005. <br /><br />2. Pimanda, J. E., Ottersbach, K., Knezevic, K., Kinston, S., Chan, W. Y. I., Wilson, N. K., Landry, J.-R., Wood, A. D., Kolb-Kokocinski, A., Green, A. R., Tannahill, D., Lacaud, G., Kouskoff, V., Gottgens, B. Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc. Nat. Acad. Sci. 104: 17692-17697, 2007. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007375-1	PA2179	-	100 ug	$370		Add to Cart
BHA21007375-2	PA2179-10ug	Sample	10 ug	$99		Add to Cart
BHA21007375-3	PA2179-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007375-4	PA2179-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007375-5	PA2179-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007375-6	PA2179-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007375-7	PA2179-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007375-8	PA2179-FITC	FITC	100 ug	$570		Add to Cart
BHA21007375-9	PA2179-HRP	HRP	100 ug	$570		Add to Cart
BHA21007375-10	PA2179-APC	APC	100 ug	$670		Add to Cart
BHA21007375-11	PA2179-PE	PE	100 ug	$670		Add to Cart
BHA21007375-12	PA2179-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007375-13	PA2179-carrier-free	carrier-free	100 ug	$370		Add to Cart

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