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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Axin 2/AXIN2 Antibody Picoband®

SKU : BHA21004308

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Mfr.No.	A01772-2, A01772-2-10ug, A01772-2-Biotin, A01772-2-Cy3, A01772-2-Dylight488, A01772-2-Dylight550, A01772-2-Dylight594, A01772-2-FITC, A01772-2-HRP, A01772-2-APC, A01772-2-PE, A01772-2-iFluor647, A01772-2-carrier-free
Alternative Names	Ubiquitin-like-conjugating enzyme ATG3
Background	Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Axin 2/AXIN2 Antibody Picoband® catalog # A01772-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1
Host	Rabbit
Immunogen Region	E.coli-derived human Axin 2/AXIN2 recombinant protein (Position: D614-D843).
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Ubiquitin-like-conjugating enzyme ATG3;6.3.2.-;Autophagy-related protein 3;APG3-like;hApg3;Protein PC3-96;ATG3;APG3, APG3L;
Tissue Specificity	Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9Y2T1
Gene Id	8313
Gene Name	AXIN2
Subcellular Location	Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Callahan, N., Modesto, A., Meira, R., Seymen, F., Patir, A., Vieira, A. R. Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis. Arch. Oral Biol. 54: 45-49, 2009. <br /><br />2. Dong, X., Seelan, R. S., Qian, C., Mai, M., Liu, W. Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene. Cytogenet. Cell Genet. 93: 26-28, 2001. <br /><br />3. Lammi, L., Arte, S., Somer, M., Jarvinen, H., Lahermo, P., Thesleff, I., Pirinen, S., Nieminen, P. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am. J. Hum. Genet. 74: 1043-1050, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004308-1	A01772-2	-	100 ug	$370		Add to Cart
BHA21004308-2	A01772-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004308-3	A01772-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004308-4	A01772-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004308-5	A01772-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004308-6	A01772-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004308-7	A01772-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004308-8	A01772-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004308-9	A01772-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004308-10	A01772-2-APC	APC	100 ug	$670		Add to Cart
BHA21004308-11	A01772-2-PE	PE	100 ug	$670		Add to Cart
BHA21004308-12	A01772-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004308-13	A01772-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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