May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.Chu W., J. Biol. Chem. 270:10236-10245(1995).Park J.-H., Cancer Res. 65:2804-2814(2005).Deloukas P., Nature 429:375-381(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ANKRD1.
Involvement In Disease
Total anomalous pulmonary venous return (TAPVR)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
Chu W., J. Biol. Chem. 270:10236-10245(1995). Park J.-H., Cancer Res. 65:2804-2814(2005). Deloukas P., Nature 429:375-381(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ANKRD1 protein.
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
Tissue Specificity
Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
Weight
36,252 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.