Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Reactivity
Human, Mouse, Rat
uniprot enrty name
PAXI_HUMAN
Note
This product is for research use only.
Clonality
polyclonal
Buffer
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Description
Phospho-Paxillin (Ser178) Antibody detects endogenous levels of Paxillin only when phosphorylated at Sersine 178. PXN is a multi-domain cytoskeletal protein that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. The SH2 domain of Crk binds to tyrosine phosphorylated paxillin. Three alternatively-spliced isoforms have been described.