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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Ebola virus EBOV(Subtype Sudan, strain Gulu) Glycoprotein/GP1(mucin domain deleted) Monoclonal Antibody

SKU : BHA10324257

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	E-AB-V1111
Background	The fourth gene of the EBOV genome encodes a 16-kDa envelope-attached glycoprotein (GP) and a 11 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD); the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, beta-integrins, folate receptor-alpha, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry; the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.
Host	Rabbit
Immunogen	Recombinant EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP1 (mucin domain deleted) Protein (His Tag)
Isotype	IgG
Reactivity	Ebola virus

Clone No	106

Buffer	0.2 um filtered solution in PBS
Concentration	1mg/mL
Purification	Protein A Affinity
Storage	Store at -20?. Avoid freeze / thaw cycles.

Applications	WB, ELISA
Dilution	WB 1:1000-1:5000 ELISA 1:5000-1:10000

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10324257	E-AB-V1111	50?L	$250		Add to Cart
BHA10324257	E-AB-V1111	100?L	$415		Add to Cart

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