DNA topoisomerase II; beta isozyme; EC 5.99.1.3; TP2B; TOP2B
Antigen
TOP2B
Categories
Primary Antibodies
Clonality
polyclonal
Description
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Ren篓 M. Linka, Nucleic Acids Res., May 2007; 10.1093.John R. Jenkins, Nucleic Acids Res., Nov 1992; 20: 5587 - 5592. Kathryn L. Gilroy, Nucleic Acids Res., Mar 2006; 34: 1597 - 1607.Sophie Dereuddre, Cancer Res., Oct 1997; 57: 4301 - 4308.
Host
Rabbit
Immunogen
Synthesized peptide derived from Internal of Human topoisomerase II β.
Involvement In Disease
A defect in TOP2B is associated with autism spectrum disorder (ASD).
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.RenM. Linka, Nucleic Acids Res., May 2007; 10.1093.John R. Jenkins, Nucleic Acids Res., Nov 1992; 20: 5587 - 5592. Kathryn L. Gilroy, Nucleic Acids Res., Mar 2006; 34: 1597 - 1607.Sophie Dereuddre, Cancer Res., Oct 1997; 57: 4301 - 4308.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total topoisomerase II β protein.