ERIC-1; ERIC1; TAC3; Transforming acidic coiled-coil-containing protein 3;
Antigen
TACC3
Categories
Primary Antibodies
Clonality
polyclonal
Description
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors By similarity. May be involved in the control of cell growth and differentiation. May contribute to cancer.Still I.H., Genomics 58:165-170(1999).McKeveney P.J. Br. J. Haematol. 112:1016-1024(2001).Gangisetty O., Oncogene 23:2559-2563(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human TACC3.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors By similarity. May be involved in the control of cell growth and differentiation. May contribute to cancer.
Still I.H., Genomics 58:165-170(1999). McKeveney P.J. Br. J. Haematol. 112:1016-1024(2001). Gangisetty O., Oncogene 23:2559-2563(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total TACC3 protein.
Subcellular Location
Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, spindle pole
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension
Protein Families
TACC family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.