Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases By similarity. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway By similarity.Heather Snyder, J. Biol. Chem., Mar 2005; 280: 7562 - 7569. Anja Leona Biere, J. Biol. Chem., Oct 2000; 275: 34574. Natalia Ninkina, Mol. Cell. Biol., Nov 2003; 23: 8233 - 8245. Zhong-Zong Pan, J. Biol. Chem., Sep 2002; 277: 35050 - 35060.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human synuclein γ.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases By similarity. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway By similarity.Heather Snyder, J. Biol. Chem., Mar 2005; 280: 7562 - 7569. Anja Leona Biere, J. Biol. Chem., Oct 2000; 275: 34574. Natalia Ninkina, Mol. Cell. Biol., Nov 2003; 23: 8233 - 8245. Zhong-Zong Pan, J. Biol. Chem., Sep 2002; 277: 35050 - 35060.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total synuclein γ protein.
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Protein Families
Synuclein family
Tissue Specificity
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.