BBP; CW17; Mammalian branch point binding protein mBBP; SF01; Splicing factor 1
Antigen
SF1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.Susan Y. Park, Development, May 2005; 132: 2415 - 2423. Dujin Zhou, Mol. Endocrinol., Jul 2000; 14: 986. Dagmar Wilhelm, Genes & Dev., Jul 2002; 16: 1839. Philipp Gut,Development, Oct 2005; 132: 4611 - 4619.
Host
Rabbit
Immunogen
Synthesized non-phosphopeptide derived from Human SF1 around the phosphorylation site of serine 82 (S-P-S(p)-P-E).
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Susan Y. Park, Development, May 2005; 132: 2415 - 2423. Dujin Zhou, Mol. Endocrinol., Jul 2000; 14: 986. Dagmar Wilhelm, Genes & Dev., Jul 2002; 16: 1839. Philipp Gut,Development, Oct 2005; 132: 4611 - 4619.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total SF1 protein.
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Protein Families
BBP/SF1 family
Tissue Specificity
Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.