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Home / Primary Antibodies / IHC Antibodies

Phospho-SYT1 (Thr202) Antibody

SKU : BHA10560440

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA438989
Alternative Names	LAG; LAP18; STN1; Prosolin; stathmin
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. E Carafoli, Crit. Rev. Biochem. Mol. Biol., Apr 2001; 36: 107. Gry Houeland, J Neurophysiol, Jan 2007; 97: 134 - 143.Christelle Carteron, J. Cell Sci., Mar 2006; 119: 898 - 909.Vladimir I. Slepnev, Science, Aug 1998; 281: 821.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 202(R-K-T(p)-L-N) derived from Human Synaptotagmin.
Involvement In Disease	A SYT1 rare mutation has been found in a child with a severe neuro-developmental disorder. The individual harboring this variant shows early onset dyskinetic movement disorder, severe motor delay and profound cognitive impairment, suggesting that SYT1 may play a role in the pathogenesis of this neuro-developmental disorder.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. E Carafoli, Crit. Rev. Biochem. Mol. Biol., Apr 2001; 36: 107. Gry Houeland, J Neurophysiol, Jan 2007; 97: 134 - 143. Christelle Carteron, J. Cell Sci., Mar 2006; 119: 898 - 909. Vladimir I. Slepnev, Science, Aug 1998; 281: 821.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Synaptotagmin only when phosphorylated at threonine 202.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle membrane, Single-pass membrane protein, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Single-pass membrane protein, Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane, Single-pass membrane protein, Cytoplasm

Uniprot	P21579
Database Links	HGNC:11509 OMIM:185605 KEGG:hsa:6857 STRING:9606.ENSP00000261205 UniGene:Hs.310545
Function	May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes
Pathway	Synaptic vesicle cycle
Protein Families	Synaptotagmin family
Tissue Specificity	Expressed in melanocytes (PubMed:23999003).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560440	CSB-PA438989	100ul	$360		Add to Cart

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