The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.Yue, C. et al. (1998) J. Biol. Chem. 273, 18023-18027. Yue, C. et al. (2000) J. Biol. Chem. 275, 30220-30225. Margolis, B. et al. (1989) Cell 57, 1101-1107.
Host
Rabbit
Immunogen
Peptide sequence around phosphorylation site of tyrosine 1217 (F-L-Y(p)-D-T) derived from Human PLCg2.
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Yue, C. et al. (1998) J. Biol. Chem. 273, 18023-18027. Yue, C. et al. (2000) J. Biol. Chem. 275, 30220-30225. Margolis, B. et al. (1989) Cell 57, 1101-1107.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of PLC-g2 onlywhen phosphorylated at tyrosine 1217.
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Pathway
Calcium signaling pathway ErbB signaling pathway HIF-1 signaling pathway VEGF signaling pathway NF-kappa B signaling pathway Ras signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Natural killer cell mediated cytotoxicity Osteoclast differentiation AGE-RAGE signaling pathway in diabetic complications Oxidative Phosphorylation Phosphatidylinositol signaling system Phospholipase D signaling pathway Inflammatory Pain Neurotrophin signaling pathway
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.