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Home / Primary Antibodies / IHC Antibodies

Phospho-NCF1 (Ser345) Antibody

SKU : BHA10560485

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA048500
Alternative Names	NCF1; P47 phox; NCF-47K;
Antigen	NCF1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).Volpp B.D., Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989).Lomax K.J., Science 245:409-412(1989).Rodaway A.R.F., Mol. Cell. Biol. 10:5388-5396(1990).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 345(P-Q-S(p)-P-G) derived from Human Nuclear p47 phox.
Involvement In Disease	Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Volpp B.D., Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989). Lomax K.J., Science 245:409-412(1989). Rodaway A.R.F., Mol. Cell. Biol. 10:5388-5396(1990).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of p47 phox only when phosphorylated at serine 345.
Subcellular Location	Cytoplasm, cytosol, Membrane, Peripheral membrane protein, Cytoplasmic side

Uniprot	P14598
Database Links	HGNC:7660 OMIM:233700 KEGG:hsa:653361 STRING:9606.ENSP00000289473 UniGene:Hs.647047
Function	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Pathway	Chemokine signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Osteoclast differentiation
Tissue Specificity	Detected in peripheral blood monocytes and neutrophils (at protein level).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560485	CSB-PA048500	100ul	$360		Add to Cart

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