Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.Tsukasa Higuchi, Mol. Cell. Biol., May 2007; 27: 3353 - 3366. NK Bhat, PNAS, May 1990; 87: 3723. H Suzuki, PNAS, May 1995; 92: 4442. V Fafeur, Cell Growth Differ., Jun 1997; 8: 655.
Host
Rabbit
Immunogen
Peptide sequence around phosphorylation site of threonine 38(L-L-T(p)-P-S) derived from Human ETS1 .
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Tsukasa Higuchi, Mol. Cell. Biol., May 2007; 27: 3353 - 3366. NK Bhat, PNAS, May 1990; 87: 3723. H Suzuki, PNAS, May 1995; 92: 4442. V Fafeur, Cell Growth Differ., Jun 1997; 8: 655.
Species
Mus Musculus (Mouse)
Specificity
The antibody detects endogenous levels of ETS1 only when phosphorylated at threonine 38.
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity).
Pathway
Cellular senescence Ras signaling pathway
Protein Families
ETS family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.