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Home / Primary Antibodies / IHC Antibodies

Phospho-ELK1 (Ser383) Antibody

SKU : BHA10560297

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA962606
Alternative Names	ELK1; ETS-domain protein Elk-1;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Elk-1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. lternatively spliced transcript variants encoding the same protein have been found for this gene.Xing J, et al. (1996) Science. 273(5277): 959-963.Janknecht R, et al. (1993) EMBO J. 12(13): 5097-5104.Marais R, et al. (1993) Cell 73: 381-393.Kortenjann M, et al. (1994) Mol Cell Biol. 14: 4815-4824.Cavigelli M, et al. (1995) EMBO J. 14: 5957-5964.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 383 (T-L-S(p)-P-I) derived from Human Elk-1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Elk-1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. lternatively spliced transcript variants encoding the same protein have been found for this gene. Xing J, et al. (1996) Science. 273(5277): 959-963. Janknecht R, et al. (1993) EMBO J. 12(13): 5097-5104. Marais R, et al. (1993) Cell 73: 381-393. Kortenjann M, et al. (1994) Mol Cell Biol. 14: 4815-4824. Cavigelli M, et al. (1995) EMBO J. 14: 5957-5964.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Elk-1 only when phosphorylated at serine 383.
Subcellular Location	Nucleus

Uniprot	P19419
Database Links	HGNC:3321 OMIM:311040 KEGG:hsa:2002 STRING:9606.ENSP00000247161 UniGene:Hs.181128
Function	Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
Pathway	ErbB signaling pathway MAPK signaling pathway Focal adhesion MAPK Erk pathway Ras signaling pathway Insulin signaling pathway
Protein Families	ETS family
Tissue Specificity	Lung and testis.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560297	CSB-PA962606	100ul	$360		Add to Cart

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