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Home / Primary Antibodies / IHC Antibodies

Phospho-CNOT2 (Ser101) Antibody

SKU : BHA10560232

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA925776
Alternative Names	NOT2H; CDC36; CNOT2; HSPC131;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. 5 isoforms of the human protein are produced by alternative splicing. Albert T.K., Nucleic Acids Res. 28:809-817(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000).Ota T., Nat. Genet. 36:40-45(2004).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine101(S-L-S(p)-Q-G) derived from Human CNOT2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. 5 isoforms of the human protein are produced by alternative splicing. Albert T.K., Nucleic Acids Res. 28:809-817(2000). Zhang Q.-H., Genome Res. 10:1546-1560(2000). Ota T., Nat. Genet. 36:40-45(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of CNOT2 only when phosphorylated at serine 101.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q9NZN8
Database Links	HGNC:7878 OMIM:604909 KEGG:hsa:4848 STRING:9606.ENSP00000229195 UniGene:Hs.133350
Function	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.
Protein Families	CNOT2/3/5 family
Tissue Specificity	Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560232	CSB-PA925776	100ul	$360		Add to Cart

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