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Home / Primary Antibodies / IHC Antibodies

Phospho-CCNC (Ser275) Antibody

SKU : BHA10560479

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA220960
Alternative Names	CG1C; cyclin C; SRB11;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.Lew D.J., Cell 66:1197-1206(1991).Li H., Genomics 32:253-259(1996).Mungall A.J., Nature 425:805-811(2003).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 275(N-G-S(p)-A-N) derived from Human Cyclin C.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. Lew D.J., Cell 66:1197-1206(1991). Li H., Genomics 32:253-259(1996). Mungall A.J., Nature 425:805-811(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Cyclin C only when phosphorylated at serine 275.
Subcellular Location	Nucleus

Uniprot	P24863
Database Links	HGNC:1581 OMIM:123838 KEGG:hsa:892 STRING:9606.ENSP00000428982 UniGene:Hs.430646
Function	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Protein Families	Cyclin family, Cyclin C subfamily
Tissue Specificity	Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560479	CSB-PA220960	100ul	$360		Add to Cart

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