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Home / Primary Antibodies / IHC Antibodies

Phospho-BCL2 (T74) Antibody

SKU : BHA10540937

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA040192
Alternative Names	BCL2; Apoptosis regulator Bcl-2
Antigen	BCL2
Categories	Primary Antibodies ; Phospho Antibodies
Conjugate	Non-conjugated
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Bcl-2 around the phosphorylation site of T74.
Involvement In Disease	A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Species	Homo Sapiens (Human)
Subcellular Location	Mitochondrion outer membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Single-pass membrane protein

Uniprot	P10415
Gene Id	596
Database Links	HGNC:990 OMIM:151430 KEGG:hsa:596 STRING:9606.ENSP00000329623 UniGene:Hs.150749
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release
Pathway	Estrogen signaling pathway Hedgehog signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway PI3K-Akt signaling pathway Focal adhesion NF-kappa B signaling pathway Apoptosis Autophagy Necroptosis Protein processing in endoplasmic reticulum NOD-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications ER Stress pathway Neurotrophin signaling pathway
Protein Families	Bcl-2 family
Tissue Specificity	Expressed in a variety of tissues.
Weight	22,337 Da

Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form	Liquid
Format	Liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications

IHC, ELISA

Description

IHC ; ELISA

Dilution

IHC	1:100-1:300
ELISA	1:10000

Tested Application

IHC,ELISA;IHC:1/100-1/300.ELISA:1/10000

Datasheet
Immunohistochemistry (IHC) Protocol
ELISA Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10540937	CSB-PA040192	100ug	$167		Add to Cart
BHA10540937	CSB-PA040192	50ug	$100		Add to Cart

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