Keratin type II cytoskeletal 5; Cytokeratin-5; CK-5; K5; 58 kDa cytokeratin
Antigen
KRT5
Categories
Primary Antibodies
Clonality
polyclonal
Description
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.Bettina Peters, Mol. Biol. Cell, Jun 2001; 12: 1775.J Casatorres, J. Biol. Chem., Aug 1994; 269: 20489 - 20496.Karin M篓绛秎er-Decker, Am. J. Pathol., Feb 2005; 166: 575 - 584.Angel Ram篓鐚篹z, Genetics, May 2001; 158: 341.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human Keratin 5.
Involvement In Disease
Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS); Epidermolysis bullosa simplex, with migratory circinate erythema (EBSMCE); Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS); Epidermolysis bullosa simplex, Koebner type (K-EBS); Epidermolysis bullosa simplex, with mottled pigmentation (MP-EBS); Dowling-Degos disease 1 (DDD1)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Bettina Peters, Mol. Biol. Cell, Jun 2001; 12: 1775. J Casatorres, J. Biol. Chem., Aug 1994; 269: 20489 - 20496. Karin M?er-Decker, Am. J. Pathol., Feb 2005; 166: 575 - 584. Angel Ram?z, Genetics, May 2001; 158: 341.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Keratin 5 protein.