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Home / Primary Antibodies / IHC Antibodies

KRT17 Antibody

SKU : BHA10559750

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA442800
Alternative Names	Keratin; type I cytoskeletal 17; Cytokeratin-17; CK-17; K17
Categories	Primary Antibodies
Clonality	polyclonal
Description	May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity.M Rosenberg, Mol. Cell. Biol., Feb 1988; 8: 722 - 736.SM Troyanovsky, J. Cell Sci., Jul 1989; 93: 419.Kevin M. McGowan, Genes & Dev., Jun 2002; 16: 1412.Nicholas Bianchi, Mol. Cell. Biol., Aug 2005; 25: 7249 - 7259."
Host	Rabbit
Immunogen	Synthesized peptide derived from Human keratin 17.
Involvement In Disease	Pachyonychia congenita 2 (PC2); Steatocystoma multiplex (SM)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity. M Rosenberg, Mol. Cell. Biol., Feb 1988; 8: 722 - 736. SM Troyanovsky, J. Cell Sci., Jul 1989; 93: 419. Kevin M. McGowan, Genes & Dev., Jun 2002; 16: 1412. Nicholas Bianchi, Mol. Cell. Biol., Aug 2005; 25: 7249 - 7259."
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total keratin 17 protein.
Subcellular Location	Cytoplasm

Uniprot	Q04695
Database Links	HGNC:6427 OMIM:148069 KEGG:hsa:3872 STRING:9606.ENSP00000308452 UniGene:Hs.2785
Function	Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin
Pathway	Estrogen signaling pathway
Protein Families	Intermediate filament family
Tissue Specificity	Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epider

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559750	CSB-PA442800	100ul	$297		Add to Cart

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