CPN60; CHAPERONIN 60-KD; GroEL E. COLI HOMOLOG OF HEAT-SHOCK 60-KD PROTEIN 1; heat shock 60kDa protein 1 (chaperonin);
Antigen
HSPD1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HAMAP-Rule MF_00600Sung Gyoo Park, J. Biol. Chem., Oct 2003; 278: 39851 - 39857.Zhiming Mai, Mol. Cell. Biol., Mar 1999; 19: 2198 - 2205.Hideaki Itoh, Eur. J. Biochem., Dec 2002; 269: 5931.Jonathan D. Cechetto, J. Histochem. Cytochem., Jan 2000; 48: 45.
Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HAMAP-Rule MF_00600
Sung Gyoo Park, J. Biol. Chem., Oct 2003; 278: 39851 - 39857. Zhiming Mai, Mol. Cell. Biol., Mar 1999; 19: 2198 - 2205. Hideaki Itoh, Eur. J. Biochem., Dec 2002; 269: 5931. Jonathan D. Cechetto, J. Histochem. Cytochem., Jan 2000; 48: 45.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total HSP60 protein.
Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix
Protein Families
Chaperonin (HSP60) family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.