Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Jenny J. Tong, Nucleic Acids Res., Mar 2002; 30: 1114 - 1123.Hung-Ying Kao, J. Biol. Chem., Jan 2002; 277: 187 - 193.Denise D. Fischer, J. Biol. Chem., Feb 2002; 277: 6656 - 6666.Matthew H. Brush, J. Biol. Chem., Feb 2004; 279: 7685 - 7691.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human HDAC10.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Jenny J. Tong, Nucleic Acids Res., Mar 2002; 30: 1114 - 1123. Hung-Ying Kao, J. Biol. Chem., Jan 2002; 277: 187 - 193. Denise D. Fischer, J. Biol. Chem., Feb 2002; 277: 6656 - 6666. Matthew H. Brush, J. Biol. Chem., Feb 2004; 279: 7685 - 7691.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total HDAC10 protein.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Protein Families
Histone deacetylase family, HD type 2 subfamily
Tissue Specificity
Ubiquitous. High expression in liver, spleen, pancreas and kidney.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.