G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.Hans H. Schiffer, J. Neurosci., Dec 2000; 20: 9025.Nathalie Strutz, J. Neurosci., Jan 2001; 21: 401.Fr篓顩娐顩榠c Jaskolski, J. Biol. Chem., Jun 2005; 280: 22968 - 22976.DE Hamassaki-Britto, J. Neurosci., May 1993; 13: 1888.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human GluR7.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Hans H. Schiffer, J. Neurosci., Dec 2000; 20: 9025. Nathalie Strutz, J. Neurosci., Jan 2001; 21: 401. Fr?ic Jaskolski, J. Biol. Chem., Jun 2005; 280: 22968 - 22976. DE Hamassaki-Britto, J. Neurosci., May 1993; 13: 1888.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total GluR7 protein.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Pathway
Oxidative Phosphorylation Phospholipase D signaling pathway Glutamatergic synapse
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.