Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.Kathryn M. Kinross, Blood, Aug 2006; 108: 886 - 895.Dawei Wang, Mol. Cell. Biol., May 2000; 20: 3417 - 3424.Stephan P. Persengiev, Mol. Cell. Biol., Sep 1999; 19: 6048 - 6056.Stefan Gaubatz, Mol. Cell. Biol., Feb 2001; 21: 1384 - 1392.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human E2F4.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.
Kathryn M. Kinross, Blood, Aug 2006; 108: 886 - 895. Dawei Wang, Mol. Cell. Biol., May 2000; 20: 3417 - 3424. Stephan P. Persengiev, Mol. Cell. Biol., Sep 1999; 19: 6048 - 6056. Stefan Gaubatz, Mol. Cell. Biol., Feb 2001; 21: 1384 - 1392.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total E2F4 protein.
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation